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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Neuropharmacology. 2021 Jun 19;195:108672. doi: 10.1016/j.neuropharm.2021.108672

Figure 1. Timeline showing the sequence of events, drug treatments, and behavioral testing.

Figure 1.

Mice were divided into groups at two points in the experimental timeline. First, at the start of the “Limited Access (2hr) Nicotine 2 Bottle Choice (2BC) Test” mice were separated into either the “UNFLAV” or “CHOICE” groups. Data from the “Initial Strawberry Preference Test” ensured that animals in each group had approximately equal baseline strawberry preference. All mice then followed the same treatment pattern, until “Nicotine Fading and Flavor Re-introduction”, when groups were further divided into one of three nicotine flavors: No Flavor, Strawberry Flavor, or Grape Flavor.