Table 3.
Diffusion measure differences of the PD and HC basal ganglia, VTA, PBP
| Region | QA | FA | MD | AD | RD | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
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| HC | PD | HC | PD | HC | PD | HC | PD | HC | PD | ||
| Putamen | L | 0.039 | 0.040 | 0.275 | 0.285 | 0.723 | 0.726 | 0.933 | 0.946 | 0.618 | 0.617 |
| R | 0.040 | 0.042 | 0.260* | 0.280* | 0.780 | 0.746 | 0.997 | 0.974 | 0.672 | 0.632 | |
| Caudate | L | 0.040 | 0.038 | 0.204 | 0.194 | 1.213 | 1.363 | 1.418 | 1.565 | 1.110 | 1.262 |
| R | 0.038 | 0.036 | 0.182 | 0.176 | 1.376 | 1.492 | 1.580 | 1.692 | 1.274 | 1.392 | |
| Nucleus accumbens | L | 0.053 | 0.059 | 0.207 | 0.218 | 0.798 | 0.808 | 0.956 | 0.980 | 0.718 | 0.722 |
| R | 0.054 | 0.054 | 0.206 | 0.206 | 0.803 | 0.834 | 0.960 | 0.997 | 0.724 | 0.752 | |
| Globus pallidus external | L | 0.032 | 0.035 | 0.333 | 0.351 | 0.713 | 0.727 | 0.959 | 0.992 | 0.590 | 0.594 |
| R | 0.038 | 0.042 | 0.338 | 0.355 | 0.777 | 0.756 | 1.056 | 1.047 | 0.638 | 0.611 | |
| Globus pallidus internal | L | 0.048 | 0.048 | 0.425 | 0.429 | 0.687 | 0.699 | 1.006 | 1.029 | 0.527 | 0.534 |
| R | 0.051 | 0.053 | 0.426 | 0.435 | 0.738 | 0.720 | 1.085 | 1.074 | 0.565 | 0.543 | |
| Substantia Nigra pars compacta | L | 0.061 | 0.060 | 0.435 | 0.450 | 0.778 | 0.778 | 1.150 | 1.163 | 0.592 | 0.586 |
| R | 0.063 | 0.061 | 0.430 | 0.452 | 0.769 | 0.764 | 1.132 | 1.143 | 0.587 | 0.574 | |
| Substantia Nigra pars reticular | L | 0.067 | 0.066 | 0.556 | 0.568 | 0.756 | 0.756 | 1.241 | 1.257 | 0.515 | 0.506 |
| R | 0.062 | 0.062 | 0.513 | 0.540 | 0.812 | 0.790 | 1.277 | 1.277 | 0.580 | 0.548 | |
| Subthalamic nucleus | L | 0.056 | 0.055 | 0.520 | 0.521 | 0.706 | 0.688 | 1.105 | 1.083 | 0.507 | 0.491 |
| R | 0.057 | 0.055 | 0.491 | 0.501 | 0.741 | 0.704 | 1.135 | 1.090 | 0.544 | 0.511 | |
| Parabrachial pigmented nucleus | L | 0.059 | 0.055 | 0.445 | 0.441 | 0.712 | 0.712 | 1.048 | 1.039 | 0.544 | 0.549 |
| R | 0.058 | 0.054 | 0.436 | 0.444 | 0.727 | 0.709 | 1.062 | 1.035 | 0.559 | 0.546 | |
| Ventral tegmental area | L | 0.077 | 0.072 | 0.470 | 0.475 | 0.733 | 0.706 | 1.086 | 1.054 | 0.556 | 0.532 |
| R | 0.076 | 0.072 | 0.450 | 0.464 | 0.749 | 0.755 | 1.092 | 1.106 | 0.578 | 0.579 | |
Average diffusion measures of left and right basal ganglia structures. Significant differences and p-values were calculated using student t-tests, with p-values adjusted for multiple corrections using FDR correction. Bolded values represent diffusion measures with significant difference (p<0.05), values with asterisk represent measures with significant difference after FDR correction. FA, Fractional Anisotropy; QA, Quantitative Anisotropy; MD, Mean Diffusivity; AD, Axial Diffusivity; RD, Radial Diffusivity.