Table 1.

The pharmacokinetic parameters of ICR mice after oral administration of berberine (BBR) simulated by a two-compartment model.

Parameters	BBR (200 mg/kg)	BBR (200 mg/kg) + voriconazole (30 mg/kg)
AUC(0–24 h) (ng/mL·h)	272.21 ± 68.42	298.93 ± 56.35
AUC(0−∞) (ng/mL·h)	333.61 ± 79.26	388.00 ± 103.32
MRT(0–24 h) (h)	7.39 ± 1.71	6.50 ± 1.40
MRT(0−∞) (h)	12.73 ± 5.85	10.43 ± 2.32
t1/2 (h)	8.44 ± 5.55	9.91 ± 5.26
Cmax (ng/mL)	44.26 ± 10.44	64.50 ± 20.12

Data are presented as mean ± SD. MRT: mean residence time.