Table 2.
Effect of BPHE against sodium oxalate induced urolithiasis in rats - Urine parameters.
Sr. no | Groups | Treatment | Oxalate (mg/dL) | Uric acid (mg/dL) | Magnesium (mg/dL) | Creatinine (mg/dL) | Phosphorus mg/dl |
---|---|---|---|---|---|---|---|
1 | Normal | 0.5% (w/v) gum acacia solution (5 ml/kg p.o.) | 0.73 ± 0.004 | 0.16 ± 0.006 | 0.83 ± 0.005 | 1.59 ± 0.03 | 0.87 ± 0.01 |
2 | Control | Sodium oxalate 70 mg/kg, i.p. | 1.93 ± 0.004 | 2.32 ± 0.02 | 0.34 ± 0.006 | 3.61 ± 0.14 | 1.43 ± 0.01 |
3 | Standard | 500 mg/kg, p.o. Cystone suspended in gum acacia 0.5% + Sodium oxalate 70 mg/kg | 0.87 ± 0.005∗∗ | 1.60 ± 0.02∗∗ | 0.69 ± 0.005∗∗ | 1.65 ± 0.04∗∗ | 0.82 ± 0.02∗∗ |
4 | BPHE | 50 mg/kg,b.wt.p.o suspended in gum acacia 0.5% + Sodium oxalate 70 mg/kg | 1.31 ± 0.04∗ | 1.93 ± 0.01∗ | 0.45 ± 0.007∗ | 2.60 ± 0.05∗ | 1.02 ± 0.01∗ |
5 | BPHE | 100 mg/kg,b.wt.p.o suspended in gum acacia 0.5% + Sodium oxalate 70 mg/kg | 0.95 ± 0.004∗∗ | 1.80 ± 0.01∗ | 0.55 ± 0.008∗ | 1.90 ± 0.02∗ | 0.94 ± 0.01∗ |
6 | BPHE | 200 mg/kg,b.wt.p.o suspended in gum acacia 0.5% + Sodium oxalate 70 mg/kg | 0.91 ± 0.006∗∗ | 1.63 ± 0.01∗∗ | 0.64 ± 0.008∗∗ | 1.79 ± 0.02∗∗ | 0.94 ± 0.01∗ |
∗P < 0.05, ∗∗P < 0.01 values are mean ± SEM, n = 6, when compared with control by using one way ANOVA followed by Dunnette's multiple comparison test. ANOVA: Analysis of variance, SEM: Standard error of mean, BPHE: Bryophyllum pinnatum hydroalcoholic extracts.