Table 2.
Absolute initial values of mechano-calorimetrical parameters in each experimental hearts group before applying I/R, and statistical results of one-way ANOVA. ∗p < 0.05 vs. the respective non-treated rats (control).
| Experimental group (n) | P (mm Hg) | +P/P (s−1) | -P/P (s−1) | tc1 (s) | tc2 (s) | tR1 (s) | tR2 (s) | Ht (mW/g) | P/Ht (mmHg.g/mW) |
|---|---|---|---|---|---|---|---|---|---|
| Young male rats (YM) | |||||||||
| Control (n = 6) | 84.4 ± 6.0 | 13.2 ± 0.9 | −15.0 ± 2.1 | 0.12 ± 0.01 | 0.05 ± 0.01 | 0.06 ± 0.01 | 0.07 ± 0.02 | 19.0 ± 1.8 | 4.6 ± 0.6 |
| DAZ (n = 9) | 86.9 ± 7.9 | 19.8 ± 1.1∗ | −13.1 ± 0.4 | 0.09 ± 0.01 | 0.03 ± 0.01∗ | 0.06 ± 0.01 | 0.07 ± 0.01 | 18.5 ± 1.1 | 4.7 ± 0.3 |
| ISOF (n = 18) | 71.5 ± 6.1 | 19.7 ± 1.1∗ | −15.1 ± 0.8 | 0.07 ± 0.01∗ | 0.03 ± 0.01∗ | 0.05 ± 0.01 | 0.07 ± 0.01 | 16.2 ± 0.9 | 4.4 ± 0.3 |
| MACA (n = 15) | 68.7 ± 5.8 | 21.1 ± 0.9∗ | −16.4 ± 0.7 | 0.05 ± 0.01∗ | 0.04 ± 0.01∗ | 0.05 ± 0.01 | 0.06 ± 0.01 | 14.2 ± 1.3 | 5.0 ± 0.4 |
| 1-way ANOVA | F = 1.578 P > 0.1, ns |
F = 4.512 P < 0.01 |
F = 2.279 P > 0.05, ns |
F = 7.768 P < 0.001 |
F = 4.653 P < 0.01 |
F = 0.4769 P > 0.5, ns |
F = 0.3236 P > 0.5, ns |
F = 2.947 P < 0.05 |
F = 0.5894 P > 0.5, ns |
| Young female rats (YF) | |||||||||
| Control (n = 6) | 71.0 ± 14.0 | 18.0 ± 1.5 | −15.7 ± 1.3 | 0.13 ± 0.02 | 0.03 ± 0.01 | 0.05 ± 0.01 | 0.07 ± 0.01 | 14.4 ± 2.5 | 4.9 ± 0.2 |
| DAZ (n = 4) | 89.4 ± 28.2 | 20.9 ± 2.1 | −11.9 ± 1.0∗ | 0.06 ± 0.01∗ | 0.03 ± 0.01 | 0.07 ± 0.01∗ | 0.10 ± 0.01 | 19.5 ± 6.3 | 4.6 ± 0.3 |
| ISOF (n = 7) | 55.6 ± 10.6 | 17.7 ± 1.1 | −14.5 ± 0.8 | 0.12 ± 0.02 | 0.04 ± 0.01 | 0.05 ± 0.01 | 0.07 ± 0.02 | 13.1 ± 2.1 | 4.2 ± 0.2 |
| MACA (n = 18) | 93.3 ± 6.1 | 18.5 ± 0.8 | −13.3 ± 0.3∗ | 0.06 ± 0.01∗ | 0.04 ± 0.01 | 0.05 ± 0.01 | 0.08 ± 0.01 | 20.3 ± 1.4 | 4.8 ± 0.4 |
| 1-way ANOVA | F = 2.664 P > 0.05, ns |
F = 0.8901 P > 0.1, ns |
F = 3.543 P < 0.05 |
F = 10.35 P < 0.0001 |
F = 4.360 P < 0.05 |
F = 6.001 P < 0.01 |
F = 1.440 P > 0.1, ns |
F = 2.493 P > 0.05, ns |
F = 0.3885 P > 0.5, ns |
| Aged female rats (AgF) | |||||||||
| Control (n = 5) | 65.5 ± 7.0 | 20.7 ± 0.9 | −19.4 ± 1.0 | Not measured | Not measured | Not measured | Not measured | 17.0 ± 1.2 | 4.8 ± 0.4 |
| MACA (n = 4) | 35.0 ± 10.0 | 22.5 ± 3.4 | −18.4 ± 3.7 | 0.05 ± 0.01 | 0.04 ± 0.01 | 0.04 ± 0.01 | 0.08 ± 0.02 | 17.0 ± 5.0 | 3.0 ± 1.0 |
| t-test | t = 2.584 df = 7, p < 0.05 |
t = 0.5681, df = 7, ns |
t = 0.2862 df = 7, ns |
t = 0.004341 df = 7, ns | t = 0.9202 df = 7, ns | ||||