Table 3.

Changes in the diastolic intraventricular pressure (ΔLVEDP, in mm Hg) over the preischemic values, at 5 and 30 min ischemia (I) and at 5 and 45 min of reperfusion (R) in the different protocols assessed. Two way- ANOVA results, ∗p < 0.05 vs control (n).

Experimental group (n)	I 5′	I 30′		R 5′		R 45′
Young male rats (YM)
Control (6)	−6.3 ± 3.0	7.5 ± 3.8		17.9 ± 2.6		16.2 ± 3.8
DAZ (5)	5.8 ± 1.5	44.8 ± 6.3		43.5 ± 4.7		25.9 ± 2.2
ISOF (5)	20.0 ± 6.4	22.8 ± 7.4		42.8 ± 6.8		23.3 ± 5.7
MACA (5)	14.2 ± 7.9	27.0 ± 5.2		51.4 ± 14.9		34.2 ± 12.9
DAZ + 5HD (4)	0.5 ± 2.5	44.8 ± 8.4		109.6 ± 14.5∗		69.9 ± 6.7∗
ISOF + 5HD (4)	26.4 ± 16.3	59.7 ± 5.4∗		78.7 ± 12.2∗		47.7 ± 8.6
ISOF + l-NAME (4)	8.5 ± 4.3	38.5 ± 3.7		73.1 ± 11.1∗		49.6 ± 5.4
ISOF + l-NAME + 5HD (5)	7.6 ± 6.3	48.6 ± 6.5∗		83.8 ± 7.9∗		75.0 ± 7.4∗
MACA + Che (5)	18.4 ± 8.9	17.0 ± 6.2		42.4 ± 7.1		9.8 ± 6.6
MACA + 5HD (5)	0.8 ± 2.0	32.6 ± 6.1		43.5 ± 10.1		28.0 ± 7.9
Two-way ANOVA:
By treatment: F = 18.07, DFn = 9, DFd = 152, P < 0.0001
By time: F = 71.70, DFn = 3, DFd = 152, P < 0.0001
Young female rats (YF)
Control (6)	17.1 ± 12.6	12.5 ± 4.9		52.6 ± 5.0		31.4 ± 3.2
DAZ (4)	−23.1 ± 7.8	13.5 ± 12.9		56.6 ± 20.7		30.1 ± 19.9
ISOF (7)	2.0 ± 7.5	15.6 ± 8.2		37.3 ± 4.1		10.9 ± 6.0
MACA (6)	−7.7 ± 6.1	27.9 ± 8.4		88.7 ± 18.4∗		74.4 ± 20.2
MACA + l-NAME + 5HD (5)	14.8 ± 20.0	29.4 ± 12.9		78.8 ± 13.2		62.1 ± 14.2
MACA + Clzp (5)	−9.6 ± 5.2	10.3 ± 12.5		49.8 ± 14.8		40.3 ± 12.6
Two-way ANOVA:
By treatment: F = 5.094, DFn = 5, DFd = 108, P < 0.001
By time: F = 30.48, DFn = 3, DFd = 108, P < 0.0001
Aged female rats (AgF)
Control (5)	16.2 ± 6.8		23.8 ± 4.7		80.3 ± 6.7		74.9 ± 9.1
MACA (4)	−3.8 ± 2.8		5.0 ± 3.7		32.6 ± 13.7∗		19.4 ± 11.1∗
Two-way ANOVA:
By treatment: F = 39.64, DFn = 1, DFd = 28, P < 0.0001
By time: F = 18.88, DFn = 3, DFd = 28, P < 0.0001