Table 2.
Sequence analysis of neutralization antibodiesa (purified mAbs).
| rSP specific mAbs | V gene (Heavy Chain) | Number of mutations and gaps, and identity compared to Germline (Heavy Chain) | V gene (Light Chain) | Number of mutations and gaps and Identity compared to Germline (Light Chain) |
|---|---|---|---|---|
| F459G1 | IGHV1-26*01 | 15 (84.7%) | IGKV6-20*01 | 3 (96.8%) |
| F461G8 | IGHV1-53*01 | 24 (75.5%) | IGKV6-15*01 | 6 (93.7%) |
| F461G11 | IGHV5-9-1*01 | 5 (94.9%) | IGKV6-20*01 | 19 (80.0%) |
| F461G14 | IGHV5-9-1*01 | 3 (96.9%) | IGKV4-80*01 | 17 (81.9%) |
| F461G15 | IGHV5-9-1*01 | 6 (93.9%) | IGKV4-80*01 | 18 (81.1%) |
| F461G16 | IGHV5-9-1*01 | 13 (87.7%) | IGKV4-80*01 | 18 (81.1%) |
a
: the germline genes were based on the highest scores in the alignments; rSP: recombinant spike protein.