FIGURE 2.

Tumour‐infiltrating immune cell (TIIC) profiles of adrenocortical carcinoma (ACC). (A) Scaled absolute value of tumour infiltration by immune cell types estimated by CIBERSORTx in ACC tumours and stratified into subgroups by cortisol secretion, abs, absolute arbitrary units; ns = p‐value ≥ 0.05; *p‐value < 0.05. (B) Impact of differentially expressed TIIC subtypes (CD8 T cells, activated natural killer cells, M1 macrophages, activated dendritic cells) on overall (OS) and disease‐free survival (DFS). Regression analysis, expressed as univariate Cox regression hazard ratio (HR) and 95% confidence interval (95% CI): HR [lower 95% CI – higher 95% CI], bold = p‐value < 0.05