FIGURE 4.

The effect of EV‐miRNA‐22 on the pathology of SCI rats. (A) Haematoxylin and eosin staining of spinal cord tissue in rats. Cells in the spinal cord were severely damaged in rats of SCI model, with obvious oedema and inflammation. Cell injury was significantly attenuated and inflammatory response was decreased in EV and EV‐miRNA‐22 groups. The scar tissue and inflammatory response in EV‐miRNA‐22 group was milder than EV group. (B) Nissl staining. Cell injury was obvious in SCI, with sparse positive cells, which was significantly different from Sham group. Cell injury was significantly relieved in EV and EV‐miRNA‐22 groups. (C and D) The expression of GSDMD and p30‐GSDMD was significantly up‐regulated in SCI than that of Sham group; while the expression of GSDMD and p30‐GSDMD was significantly decreased in EV and EV‐miRNA‐22 groups than that in SCI group