FIGURE 5.

Immune microenvironment infiltration characterization. (A) Heat map of the abundance differences of each immune microenvironment infiltrating immunocyte in each group. (B and C) Box plot of the abundance differences of each immune microenvironment infiltrating immunocyte and HLA genes in healthy controls and severe asthma cases. (D and E) Box plot of the abundance differences of each immune microenvironment infiltrating immunocyte and HLA genes in 3 m6A modification patterns. (F) The correlation analysis of the m6A differentially expressed genes (GEGs). The most positive correlated immunocyte‐m6A regulator pair is EIF3A‐effector memory CD4 T cell, the most negative correlation was YTHDC1‐myeloid‐derived suppressor cell, and the fraction status is presented at up panel. The abundance of eosinophils is positively correlated with YTHDF3 and negatively correlated with EIF3B; the fraction status is presented at down panel. (G) The correlation between HLA genes and m6A DEGs