Table 2.

List of studies included for circulating IL-6 endpoint

Studies	Year	Ancestry	Sample size [‘C’ allele carriers (CC + GC)/wild type genotype (GG)]	IL-6 levels (pg/ml) in ‘C’ allele carriers (CC and GC)	IL-6 levels (pg/ml) in wild type genotype (GG)
CAD cases
Basso et al. [29]	2002	European	117/60	2:95 ± 3.67	2.99 ± 3.23
Bennet et al. [31]	2003	European	852/295	1.59 ± 2.90	1.73 ± 3.40
Kelberman et al.(a) [33]	2004	European	117/76	1.67 ± 1.11	1.83 ± 1.22
Kelberman et al.(b) [33]	2004	European	78/87	2.22 ± 1.48	2.20 ± 1.47
Lieb et al. [35]	2004	European	476/211	2.12 ± 9.50	2.00 ± 8.43
Bennermo et al. [46]	2011	European	237/119	0.79 ± 1.72	0.81 ± 1.87
Satti et al. [65]	2013	Asian Indian	18/18	51.55 ± 17.65	27.00 ± 4.00
Biswas et al. [66]	2014	Asian Indian	152/348	28.09 ± 108.71	12.60 ± 33.54
Toutouzas et al. [74]	2017	European	127/30	4.71 ± 2.29	2.71 ± 1.08
CAD free controls
Basso et al. [29]	2002	European	183/98	2.63 ± 3.13	2.66 ± 2.68
Bennet et al. [31]	2003	European	1102/398	1.29 ± 0.72	0.93 ± 2.25
Kelberman et al. (North Europe) [33]	2004	European	156/62	1.29 ± 0.72	1.20 ± 0.67
Kelberman et al. (South Europe) [33]	2004	European	95/103	1.28 ± 0.85	1.14 ± 0.75
Bennermo et al. [46]	2011	European	269/109	0.66 ± 0.91	0.58 ± 0.65
Biswas et al. [66]	2014	Asian Indian	407/407	10.1 ± 55.63	7.28 ± 6.71