Table 1.
General clinical characteristics and autopsy findings of our cohort
| Findings | |
|---|---|
| Male/female | 32/25 |
| Age | Mean: 74, median: 77, range: 33–96 years |
| Duration of disease | Mean: 7 years, median: 3 years, range: < 1–50 years |
| Type of disease | CMML: 18 |
| ET: 1 | |
| PV: 16 | |
| PMF: 16 | |
| MPN other: 6 | |
| Hematopoetic cell transplantation | 11/57 |
| Cause of death | Cardiac disease: 11/57 |
| HCT-related: 2/57 | |
| Infectious diseases: 27/57 | |
| Hemorrhagic shock: 4/57 | |
| Lung embolism: 9/57 | |
| Tumor progression: 4/57 | |
| Kidney function* | G1: 17/55 |
| G2: 27/55 | |
| G3a: 6/55 | |
| G3b: 3/55 | |
| G4: 2/55 | |
| Idiopathic diffuse glomeruloclerosis | 7/57 |
| Diabetic glomerulosclerosis | 2/57 |
| Diabetes | 2/57 |
| Arteriolosclerosis | 18/57 |
| Shock signs | 8/57 |
| Florid pyelonephritis | 2/57 |
| Extramedullary hematopoesis in the kidney | 5/57 |
| Infiltration of the kidney by blastoid cells | 3/57 |
| Other non-specific findings** | 29/57 |
| No renal involvement | 9/57 |
*Laboratory parameters were available of 55/57 patients.
**This includes simple cysts, small vascular scars, mild nephrocalcinosis, and papillary adenoma.