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Current guideline directed approach (Class I indications 2021 ESC guidelines). HFrEF, Heart failure with reduced Ejection fraction; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; MRA, mineralocorticoid receptor antagonist; SGLT2, sodium-glucose cotransporter 2; AF, atrial fibrillation; LVEF, left ventricle ejection fraction; CRT, cardiac resynchronization therapy; MR, mitral regurgitation.
