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. 2021 Nov 8;11:568. doi: 10.1038/s41398-021-01689-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Experimental and proteomics workflow of the study. B There were no differences in weight, total motion distance, and percentage of time spent in the center of the OFT between “depression microbiota” and “healthy microbiota” recipients. The “depression microbiota” recipients displayed an increased duration of immobility in the FST compared with “healthy microbiota” recipients (*p < 0.05, t test). The gray bars indicate the “healthy microbiota” recipients (n = 20). The green bars indicate the “depression microbiota” recipients (n = 24). C Volcano plots of detected protein abundance from the four tissues. Green, orange, blue, and red dots indicate DE proteins in the PFC, liver, cecum, and serum, respectively.