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. 2021 Oct 25;8:671001. doi: 10.3389/fcvm.2021.671001

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Copyright © 2021 Lestuzzi, Mascarin, Coassin, Canale and Turazza.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Echocardiograms of a patient treated with anthracyclines chemotherapy and mediastinal RT in 1999, at age 19. He underwent a cardiologic follow-up every 2–3 years. In February, 2014 (images on the left) the echocardiogram detected the new appearance of mild aortic and mitral dysfunction (A,B); the left ventricular (LV) function and Global Longitudinal Strain (GLS) were normal (C); a stress test was negative. We planned yearly check-up, but the patient, who felt completely asymptomatic, skipped the appointments. In February 2018, at age 38, he suddenly experienced a congestive heart failure. The echocardiogram (images on the right) showed: calcific aortic stenosis, severe mitral regurgitation (A); severe aortic stenosis and moderate aortic regurgitation (B); severe LV dysfunction and abnormal GLS (C). At coronary angiography a 70% stenosis of the left anterior descending coronary artery was detected.