Table 3.
Anatomical locations of peak coordinates and cluster size for each contrast ALE comparing PWA and controls.
| Condition | Anatomical location | Peak coordinates | Voxels (mm3) |
|---|---|---|---|
| Production and comprehension | |||
| Conjunction analysis | Left inferior frontal gyrus (pars triangularis)*, left middle frontal gyrus | −44, 28, 16 | 7,608 |
| Left medial frontal gyrus* | −6, 14, 44 | 8 | |
| Left superior frontal gyrus* | −4, 6, 54 | 768 | |
| Left superior temporal gyrus*, left middle temporal gyrus | −56, −42, 6 | 2,544 | |
| Left superior temporal gyrus* | −56, −24, 0 | 24 | |
| Left superior temporal gyrus* | −56, −26, 2 | 24 | |
| Right insula*, right inferior frontal gyrus (pars orbitalis, pars triangularis) | 36, 22, 0 | 1,944 | |
| Right medial frontal gyrus* | 8, 8, 46 | 8 | |
| Right middle temporal gyrus*, right superior temporal gyrus | 54, −36, 4 | 1,232 | |
| PWA > Controls | Right inferior frontal gyrus (pars triangularis*) | 54, 14, 20 | 208 |
| Controls > PWA | Left inferior frontal gyrus (pars opercularis)*, left middle frontal gyrus, left precentral gyrus | −42.6, 10, 26 | 7,832 |
| Left inferior frontal gyrus (pars triangularis)* | −36, 24, 6 | 1,408 | |
| Left middle temporal gyrus*, left superior temporal gyrus | −50, −46, 4 | 1,104 | |
| Left superior temporal gyrus* | −60, −26, 8 | 1,040 | |
| Left superior temporal gyrus* | −53, 8, −8 | 384 | |
| Left superior parietal lobule* | −32, −60, 42 | 1,376 | |
| Right medial frontal gyrus*, left superior frontal gyrus, left medial frontal gyrus | 2.2, 16.9, 46.4 | 3,064 | |
| Right superior temporal gyrus* | 54, 12, −6 | 1,192 | |
| Production | |||
| Conjunction analysis | Left middle frontal gyrus* | −42, 26, 18 | 1,112 |
| Right insula*, right inferior frontal gyrus (pars triangularis) | 36, 22, 2 | 632 | |
| Right superior temporal gyrus*, right middle temporal gyrus | 62, −26, 2 | 1,056 | |
| Controls > PWA | Left inferior frontal gyrus (pars opercularis*, pars triangularis), left insula | −49.2, 12.8, 21.2 | 7,720 |
| Left superior frontal gyrus*, left medial frontal gyrus | −2.2, 15.7, 52.3 | 3,648 | |
| Left middle temporal gyrus*, left superior temporal gyrus | −54, −44, 2 | 2,232 | |
| Right inferior frontal gyrus (pars triangularis*) | 54, 22, 2 | 240 | |
| Right middle temporal gyrus* | 48, −40, 8 | 408 | |
| Right superior temporal gyrus* | 62, −26, 8 | 616 | |
| Right superior temporal gyrus* | 54, 12, −6 | 496 | |
| Comprehension | |||
| Conjunction Analysis | Left inferior frontal gyrus (pars orbitalis)* | −40, 30, −10 | 1,168 |
| Left inferior frontal gyrus (pars opercularis)*, left middle frontal gyrus | −44, 14, 22 | 768 | |
| Left inferior frontal gyrus (pars triangularis)* | −46, 22, 12 | 584 | |
| Left middle temporal gyrus* | −54, −40, 0 | 2,136 | |
| PWA > Controls | Left precentral gyrus* | −47, −6, 38 | 688 |
| Controls > PWA | Left middle frontal gyrus* | −42, 12, 30 | 848 |
The x, y, z coordinates are in Talairach space and refer to the peak voxel activated in each cluster. All contrast ALEs are thresholded at p = 0.05 uncorrected. Asterisks indicate anatomical location of peak voxel.