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. 2021 Oct 25;9:716184. doi: 10.3389/fbioe.2021.716184

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Copyright © 2021 Locatelli, Colciago, Castiglioni and Maier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Platelet Rich Plasma (PRP) preparation and efficacy in different clinical conditions. PRP is prepared by centrifugation of peripheral blood to concentrate platelets. Platelet derivatives are promising tools to promote regeneration and healing for future space travel. Indeed, they have yielded excellent results in different medical fields, from oral and maxillofacial surgical procedures, to the treatment of symptomatic osteoarthritis patients and diabetic ulcers. NFκB, Nuclear Factor kappa B; TGF-β, Transforming Growth Factor β MMPs, Matrix Metallo-Proteinases, 5-HT, serotonin.