FIGURE 1.

(A) From “active compounds of the drug,” to its “traditional therapeutic application,” or “pathogenesis of the disease.” (B) Bench to Bedside: Pathogenesis + Active compounds known → Therapeutic applications unknown. (C) Bedside to Bench: Pathogenesis + Therapeutic application known → Active compounds unknown. (D) Tradition to Pathogenesis: Active compounds + Therapeutic application known → Pathogenesis unknown.