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Dose adjustment and drug interactions with pharmacologic drugs used for smoking cessation
| NRT | Bupropion | Cytisine | Varenicline | |
|---|---|---|---|---|
| GFR: >50 mL/min | No adjustment | No adjustment | No adjustment | No adjustment |
| GFR: 50–30 mL/min | No adjustment | No adjustment | No data | No adjustment |
| GFR: <30 mL/min | No adjustment | Maximum 150 mg 1×/day | No data | Maximum 1 mg 1×/day |
| Drug interactions | No interaction |
|
Caution with anti-tuberculosis medications; clozapine; ropinirole; oral contraception | Cimetidine |
