Table 1.
Humoral and cellular response to SARS-CoV-2 infection stratified by disease severity and interval between infection and sampling
| Mild disease (95% CI) | Severe disease (95% CI) | P-valuea | |
|---|---|---|---|
| Period 1 (16 March 2020–30 August 2020) | n = 7 | n = 6 | |
| Anti-S IgG (GMT) | 187 (96–362) | 1306 (633–2695) | 0.003 |
| Anti-N IgG (GMT) | 1.62 (1.29–2.03) | 2.87 (2.05–4.03) | 0.016 |
| QuantiFERON (GMC) | 0.21 (0.11–0.40) | 0.69 (0.18–2.74) | 0.154 |
| Period 2 (31 August 2020–2 March 2021) | n = 17 | n = 11 | |
| Anti-S IgG (GMT) | 525 (227–1215) | 2658 (1483–4763) | 0.010 |
| Anti-N IgG (GMT) | 4.10 (2.93–5.73) | 6.18 (4.77–8.00) | 0.097 |
| QuantiFERON (GMC) | 0.20 (0.08–0.46) | 0.17 (0.05–0.62) | 0.880 |
a
According to linear models for log10-transformed outcomes. GMT, geometric mean titre; GMC, geometric mean concentration.