Table 1.

Baseline demographics of ADPKD cohort

Baseline demographic and clinical characteristics	Total cohort (n = 39) (%)
Female	23 (59)
White British	35 (90)
Age, years	47 ± 13
Positive family history	33 (85)
Disease duration, years	14.2 (7.0–25.9)
Previous surgical intervention	1 (3)
Hypertension	25 (64)
Number of antihypertensives per participant	2 (1–3)
Age of onset, years	38.7 (29.7–48.2)
Extra-renal manifestations
Hepatic cysts	23 (59)
Intracranial aneurysm	4 (10)
Cardiac valve abnormalities	2 (5)
Imaging
Large kidney size  ($\ge$16.5 cm or total kidney volume $\ge$750 mL)	27 (69)
Physical parameters
Height, cm	174.1 ± 10.8
Weight, kg	74.6 (63.0–88.0)
Body mass index	25 (22–31)
Systolic BP, mmHg	135 ± 15
Diastolic BP, mmHg	81 ± 9
Biochemical parameters
Sodium, mmol/L	139 (138–140)
Potassium, mmol/L	4.2 (4.1–4.5)
Creatinine, µmol/L	92 (64–133)
eGFR, mL/min/1.73 m2 (CKD-EPI)	76 (47–111)
CKD Stages 3 and 4 (eGFR <60 mL/min/1.73 m2)	15 (38)
Urine parameters
Urine volume, mL/day	2740 ± 1014
Urine osmolality, mOsm/kg/day	341 ± 137
Proteinuria, mg/mmol, n (%)	4 (10)
Haematuria, n (%)	11 (28)

Data are presented as mean ± SD, median (IQR) or n (%). CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration.