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. 2021 Oct 25;12:745672. doi: 10.3389/fgene.2021.745672

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Copyright © 2021 Thiecke, Yang, Burren, Ray-Jones and Spivakov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment of COGS-prioritised genes in COVID-19-response gene sets. Quantitative GSEA analysis using the COGS score for each gene against gene sets from the COVID-19 Drug and Gene Set Library. Diagnostic plots produced by the GSEA software demonstrate the relationship between the normalised enrichment score (NES) and measures of significance [(A), top plot] and the enrichment across COGS scores for the gene sets with the top two NES scores (A, middle and bottom plots) (B) Bubble-plot showing results for all gene sets. The “up” and “down” suffixes indicated the direction of differential expression in COVID-19 for the gene set in question.