TABLE 4.
Correlation analysis between GBP1/2/3/4 and related markers of immune cells in LGG.
| Description | Gene marker | GBP1 | GBP2 | GBP3 | GBP4 | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cor | p | Cor | p | Cor | p | Cor | p | ||
| Monocyte | CD86 | 0.634 | *** | 0.685 | *** | 0.565 | *** | 0.334 | *** |
| CD115 (CSF1R) | 0.450 | *** | 0.580 | *** | 0.477 | *** | 0.216 | *** | |
| TAM | IL10 | 0.548 | *** | 0.580 | *** | 0.429 | *** | 0.354 | *** |
| CCL2 | 0.652 | *** | 0.647 | *** | 0.448 | *** | 0.345 | *** | |
| CD68 | 0.640 | *** | 0.709 | *** | 0.545 | *** | 0.312 | *** | |
| FCGR2A | 0.722 | *** | 0.753 | *** | 0.593 | *** | 0.378 | *** | |
| M1 Macrophage | PTGS2 | 0.200 | *** | 0.147 | ** | 0.096 | * | 0.215 | *** |
| IRF5 | 0.580 | *** | 0.592 | *** | 0.550 | *** | 0.292 | *** | |
| CXCL10 | 0.692 | *** | 0.529 | *** | 0.466 | *** | 0.574 | *** | |
| M2 Macrophage | CD163 | 0.485 | *** | 0.636 | *** | 0.332 | *** | 0.248 | *** |
| VSIG4 | 0.471 | *** | 0.656 | *** | 0.445 | *** | 0.164 | *** | |
| MS4A4A | 0.495 | *** | 0.656 | *** | 0.447 | *** | 0.243 | *** | |
| DCs | ITGAX | 0.505 | *** | 0.451 | *** | 0.447 | *** | 0.229 | *** |
| CD1C | 0.357 | *** | 0.440 | *** | 0.266 | *** | 0.306 | *** | |
| NRP1 | 0.323 | *** | 0.287 | *** | 0.244 | *** | 0.471 | *** | |
| THBD | 0.378 | *** | 0.389 | *** | 0.216 | *** | 0.350 | *** | |
| Neutrophils | CCR7 | 0.412 | *** | 0.313 | *** | 0.261 | *** | 0.356 | *** |
| ITGAM | 0.556 | *** | 0.598 | *** | 0.547 | *** | 0.315 | *** | |
| CD59 | 0.266 | *** | 0.253 | *** | 0.132 | ** | 0.233 | *** | |
| Th1 | STAT4 | −0.087 | 0.059 | −0.282 | *** | −0.166 | *** | 0.141 | ** |
| TBX21 | 0.358 | *** | 0.282 | *** | 0.25 | *** | 0.313 | *** | |
| CD4 | 0.608 | *** | 0.707 | *** | 0.539 | *** | 0.370 | *** | |
| Th2 | CXCR4 | 0.531 | *** | 0.375 | *** | 0.371 | *** | 0.231 | *** |
| CCR4 | 0.433 | *** | 0.324 | *** | 0.312 | *** | 0.429 | *** | |
| CCR8 | 0.204 | *** | 0.143 | ** | 0.144 | ** | 0.149 | ** | |
| Treg | FOXP3 | −0.071 | 0.120 | −0.289 | *** | −0.081 | 0.077 | 0.110 | * |
| STAT5B | 0.020 | 0.662 | 0.114 | * | 0.074 | 0.107 | 0.063 | 0.171 | |
| TGFB1 | 0.563 | *** | 0.642 | *** | 0.542 | *** | 0.202 | *** | |
| Natural killer cell | KIR2DL1 | 0.053 | 0.246 | 0.035 | 0.448 | −0.004 | 0.936 | 0.104 | * |
| KIR2DL3 | 0.174 | *** | 0.217 | *** | 0.118 | * | 0.171 | *** | |
| KIR3DL1 | 0.103 | * | 0.103 | * | −0.029 | 0.521 | 0.189 | *** | |
| KIR3DL2 | 0.189 | *** | 0.175 | *** | 0.183 | *** | 0.179 | *** | |
| KIR3DL3 | −0.012 | 0.797 | 0.019 | 0.672 | 0.022 | 0.630 | −0.054 | 0.241 | |
| KIR2DS4 | 0.172 | *** | 0.198 | *** | 0.050 | 0.276 | 0.244 | *** | |
| T cell exhaustion | PDCD1(PD-1) | 0.586 | *** | 0.531 | *** | 0.401 | *** | 0.283 | *** |
| CTLA4 | 0.318 | *** | 0.288 | *** | 0.236 | *** | 0.302 | *** | |
| TIM-3 (HAVCR2) | 0.649 | *** | 0.674 | *** | 0.587 | *** | 0.334 | *** | |
| GZMB | 0.366 | *** | 0.276 | *** | 0.171 | *** | 0.405 | *** | |
| LAG3 | 0.231 | *** | 0.326 | *** | 0.185 | *** | 0.049 | 0.287 | |