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. 2021 Oct 25;8:753088. doi: 10.3389/fmed.2021.753088

Table 2.

Pregnancy outcomes (proportion of adverse outcomes to the number of exposed pregnancies) of included studies.

Outcomes group Preterm delivery Low birth weight Spontaneous abortion Congenital abnormalities
A B C D A B C D A B C D A B C D
Kammerlander et al. (17) 7/90 1/30 4/90 1/30
Zelinkova et al. (18) 3/25 1/25 4/25 0/25
Lichtenstein et al. (19) 4/78 1/40 13/78 3/40 2/78 0/40
Wils et al. (20) 5/60 5/21 4/27 2/50 4/60 5/21 2/27 2/50 3/60 3/21 3/27 4/50 1/60 2/21 1/27 1/50
Katz et al. (21) 11/82 2/82
Schnitzler et al. (22) 10/72 9/41 10/48 3/52 6/72 8/41 2/48 2/52 9/72 12/41 5/48 4/52 2/72 4/41 1/48 1/52
Weber-Schoendorfer et al. (23) 20/85 19/27 8/30 6/80 3/85 6/27 6/30 4/80 13/85 6/80 3/85 1/80
Clowse et al. (24) 5/98 6/53 3/47 4/198 2/98 3/53 2/47 4/198 10/98 9/53 4/47 10/198 3/98 5/53 1/47 2/198
Moens et al. (25) 14/136 10/40 4/24 10/86 16/136 12/40 4/24 7/86 18/136 6/40 4/24 9/86 4/136 3/40 1/24 2/86
Casanova et al. (26) 1/15 1/15 1/15 1/15 2/15 1/15 1/15 0/15
de Lima et al. (27) 5/63 2/55 6/63 2/55 2/63 1/55

A, exposed to anti-TNF; B, exposed to anti-integrins; C, exposed to anti-interleukins; D, without biologics.