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. 2021 Oct 25;12:746796. doi: 10.3389/fphys.2021.746796

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Copyright © 2021 Hopper, Cuomo, Ferruzzi, Burris, Roccabianca, Humphrey and Figueroa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regional circumferential (C_θ_θ_θ_θ) and axial (C_zzzz) material stiffness and wall thickness h for young adult and old adult humans (top) and mice (bottom) for five locations along the aorta (ATA, ascending thoracic aorta; pDTA, proximal descending thoracic aorta; dDTA, distal descending thoracic aorta; SAA, suprarenal abdominal aorta; and IAA, infrarenal abdominal aorta). The percentages indicate changes with aging relative to the young value. Note that the ATA stiffened the most with aging in humans (cf. Redheuil et al., 2010) whereas the DTA stiffened the most with aging in mice.