Table 3.
Prognostic Factors on Overall Survival by Cox Proportional-Hazards Model
| UVA | MVA in NLR Model | MVA in PLR Model | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Age >65 years | 0.79 (0.50–1.24) | 0.304 | ||||
| Female vs male | 1.47 (0.87–2.48) | 0.151 | ||||
| Underlying liver disease | ||||||
| HBV vs no | 0.79 (0.50–1.25) | 0.309 | ||||
| HCV vs no | 1.00 (0.62–1.62) | 0.987 | ||||
| CTP class B vs A | 2.07 (1.28–3.33) | 0.003 | 2.35 (1.27–4.37) | 0.007 | 2.48 (1.38–4.44) | 0.002 |
| Total GTV (per 10 cc increase) | 1.002 (0.996–1.008) | 0.566 | ||||
| Multiple tumors | 1.81 (1.09–3.03) | 0.023 | 1.99 (1.08–3.68) | 0.028 | 1.71 (0.93–3.15) | 0.083 |
| Macrovascular invasion | 2.20 (1.36–3.55) | 0.001 | 1.51 (0.87–2.62) | 0.143 | 1.92 (1.13–3.26) | 0.016 |
| Extrahepatic spread | 3.35 (1.92–5.85) | <0.001 | 1.68 (0.91–3.08) | 0.097 | 1.61 (0.85–3.04) | 0.141 |
| Performance status ≥2 | 2.01 (1.17–3.46) | 0.012 | 0.77 (0.40–1.50) | 0.443 | 1.14 (0.61–2.15) | 0.676 |
| AFP level ≥400 ng/mL | 1.67 (1.06–2.65) | 0.029 | 1.72 (1.00–2.95) | 0.051 | 1.59 (0.94–2.69) | 0.081 |
| BED ≥85.5 Gy | 1.16 (0.73–1.83) | 0.527 | ||||
| Prior treatment no. | ||||||
| 0 | Reference | 0.552 | ||||
| 1–3 | 1.30 (0.78–2.16) | 0.311 | ||||
| >3 | 1.29 (0.68–2.46) | 0.431 | ||||
| Pre-RT Hgb (per 1 g/dL increase) | 0.91 (0.82–1.00) | 0.057 | 0.97 (0.87–1.09) | 0.629 | 1.01 (0.91–1.13) | 0.860 |
| ASL | 2.33 (1.44–3.76) | 0.001 | 1.01 (0.54–1.90) | 0.971 | 1.67 (0.99–2.84) | 0.056 |
| Pre-RT NLR (per 1-unit increase) | 1.20 (1.10–1.30) | <0.001 | 1.24 (1.12–1.38) | <0.001 | ||
| Delta-NLR (per 1-unit increase) | 1.11 (1.05–1.18) | 0.001 | 1.10 (1.02–1.18) | 0.011 | ||
| Pre-RT PLR (per 10-unit increase) | 1.02 (1.00–1.05) | 0.070 | 1.00 (0.97–1.04) | 0.813 | ||
| Delta-PLR (per 10-unit increase) | 1.01 (0.99–1.02) | 0.401 | ||||
Abbreviations: AFP, α-fetoprotein; ASL, acute severe lymphopenia; BED, biologically effective dose; CI, confidence interval; CTP, Child–Turcotte–Pugh liver function scale; GTV, gross tumor volume; HBV, hepatitis B virus; HCV, hepatitis C virus; Hgb, hemoglobin; HR, hazard ratio; MVA, multivariable analysis; NLR, neutrophil-to-lymphocyte ratio; OS, overall survival; PLR, platelet-to-lymphocyte ratio; RT, radiotherapy; UVA, univariable analysis.