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. 2021 Oct 25;11:701736. doi: 10.3389/fonc.2021.701736

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Copyright © 2021 Dong, Chen, Deng, Zhang, Dong and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combined analysis of H2AFZ expression and TP53 status improves prognostic value of HCC patient outcome. (A) Overall survival and progression-free survival of TP53^mut and TP53^wt patients. (B) Overall survival and progression-free survival of the four subgroups (G1: H2AFZ^high/TP53^mut; G2: H2AFZ^high/TP53^wt; G3: H2AFZ^low/TP53^mut; G4: H2AFZ^low/TP53^wt). (C) Expression levels of immune-checkpoint-relevant transcripts in the four subgroups, respectively *p < 0.05; **p < 0.001; ***p < 0.0001; ns, not significant.