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. 2021 Oct 25;11:701736. doi: 10.3389/fonc.2021.701736

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Copyright © 2021 Dong, Chen, Deng, Zhang, Dong and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of H2AFZ and immune infiltrations in HCC. (A) The score distribution of CD4+ T cells, neutrophils, macrophages, CD8+ T cells, B cells, and myeloid dendritic cells in the H2AFZ^high group and H2AFZ^low group, estimated by TIMER. (B) Scores of monocytes, macrophage M0, macrophage M1, macrophage M2, naive CD4+ T cells, Th1 cells, Th2 cells, and Tregs in the H2AFZ^high group and the H2AFZ^low group, estimated by CIBERSORT and xCell (Mann–Whitney tests, *p < 0.05, **p < 0.001, ***p < 0.0001). (C) Differential H2AFZ expression level in Th1/Th2^high patients and Th1/Th2^low patients (Mann–Whitney test, p < 0.00001). (D) Expression levels of immune-checkpoint-relevant transcripts in the H2AFZ^high and H2AFZ^low group, respectively (Mann–Whitney tests, *p < 0.05, **p < 0.001, ***p < 0.0001).