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. 2021 Oct 25;12:757666. doi: 10.3389/fphar.2021.757666

FIGURE 1.

FIGURE 1

EPs 7630 inhibits the propagation of highly pathogenic coronaviruses. (A) Comparison of virus growth of SARS-CoV, MERS-CoV, and SARS-CoV-2 in VeroFM and Calu-3 cells using an MOI of 0.0005 and indicated concentrations of EPs 7630. Virus-containing supernatants were collected 48 h post-infection and viral titers were determined as plaque-forming units (PFU)/ml by plaque titration assay. Bars represent mean values and SD from n = 3 biological samples. Statistical significance (treatment vs control) is indicated by (*) as determined by unpaired t-test with Welch´s correction. (*) = p<0.05; (**) = p<0.01. Control = medium only. (B) SARS-CoV-2 IC50 determination (plaque titration) and cell viability assay (CellTiter Glo 2.0) in VeroFM and Calu-3 cells at 48 h post-treatment/-infection. Data are shown as percent of untreated cells and represent mean values from at least n = 3 biological samples.