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. 2021 Oct 25;12:757666. doi: 10.3389/fphar.2021.757666

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Copyright © 2021 Papies, Emanuel, Heinemann, Kulić, Schroeder, Tenner, Lehner, Seifert and Müller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EPs 7630 treatment limits SARS-CoV-2-induced inflammation in Calu-3 lung cells. Supernatants from EPs 7630-treated (100 μg/ml) and EPs 7630-treated and SARS-CoV-2 infected (MOI = 0.0005) Calu-3 cells were analyzed at 8 and 48 h post-infection using the Human Cytokine/Chemokine/Growth Factor Multiplex Assay (Merck Millipore) with the Luminex MAGPIX System according to the manufacturer’s instructions. Data are derived from n = 3 biological samples (for IL-1β, CXCL10/IP10: n = 2–3). Vehicle = medium only. Statistical significance is indicated by (*) as determined by two-way ANOVA with Tukey’s multiple comparison test. Asterisks are shown only for significantly different data sets. (*) = p < 0.05; (**) = p < 0.01; (***) = p < 0.001; (****) = p < 0.0001.