TABLE 2.

Association of GIPR variants, R190Q and E288G with relevant dichotomous phenotypes.

Trait	R190Q (rs139215588)					E288G (rs143430880)					References
	EAF	OR	95% CI	P	N	EAF	OR	95% CI	P	N
Fracture risk	0.0014	1.001	0.80–1.25	0.99	426,795	0.0019	0.995	0.86–1.15	0.94	426,795	Morris et al., 2019
T2D	0.0015	1.19	0.84–1.69	0.56	298,957	0.0017	0.82	0.65–1.04	0.17	298,957	Mahajan et al., 2018
T2D, BMI adj.	0.0015	1.30	0.93–1.81	0.28	298,957	0.0017	0.76	0.60–0.96	0.04	298,957	Mahajan et al., 2018
	EAF	Z-score		P	N	EAF	Z-score		P	N
Hypertension	0.0016	1.78		0.07	614,250	0.0087	1.71		0.09	548,903	Surendran et al., 2020

EAF, effect allele frequency; SE, standard error; P, p-value; N, sample size; OR, odds ratio; BMI adj., body mass index adjusted.