Table 3.
Clinical features of 83 AAV patients in ICU.
| Characteristics (n, %) |
Total (n = 83) |
Survivors (n = 39) |
Non-survivors (n = 44) |
P -value |
|---|---|---|---|---|
| Fever | 48 (57.8) | 20 (51.3) | 28 (63.6) | 0.255 |
| Respiratory system | ||||
| Cough | 31 (37.3) | 14 (35.9) | 17 (38.6) | 0.797 |
| Hemoptysis | 11 (13.3) | 4 (10.3) | 7 (15.9) | 0.448 |
| Diffuse alveolar hemorrhage | 19 (22.9) | 7 (17.9) | 12 (27.3) | 0.313 |
| Interstitial lung disease | 25 (30.1) | 10 (25.6) | 15 (34.1) | 0.402 |
| Pleural effusions | 48 (57.8) | 22 (56.4) | 26 (59.1) | 0.805 |
| Pulmonary embolism | 3 (3.6) | 1 (2.6) | 2 (4.5) | 1.000 |
| Pulmonary arterial hypertension | 13 (15.7) | 1 (2.6) | 12 (27.3) | 0.002 |
| Respiratory failure | 51 (61.4) | 9 (23.1) | 42 (95.5) | <0.001 |
| Renal disease | ||||
| Renal insufficiency | 59 (71.1) | 24 (61.5) | 35 (79.5) | 0.071 |
| Glomerulonephritis | 38 (45.8) | 14 (35.9) | 24 (54.5) | 0.089 |
| Cardiovascular disease | ||||
| Heart failure | 53 (63.9) | 22 (56.4) | 31 (70.5) | 0.184 |
| Acute myocardial infarction | 5 (6.0) | 1 (2.6) | 4 (9.1) | 0.432 |
| Arrhythmia | 3 (3.6) | 1 (2.6) | 2 (4.5) | 1.000 |
| Digestive system | ||||
| Gastrointestinal bleeding | 10 (12.0) | 4 (10.3) | 6 (13.6) | 0.893 |
| Bowel obstruction | 2 (2.4) | 1 (2.6) | 1 (2.3) | 1.000 |
| Hypoalbuminemia | 45 (54.2) | 21 (53.8) | 24 (54.5) | 0.949 |
| Liver dysfunction | 10 (12.0) | 2 (5.1) | 8 (18.2) | 0.137 |
| Neuropsychiatric disease | ||||
| Stroke | 14 (16.9) | 2 (5.1) | 12 (27.3) | 0.007 |
| Others a | 3 (3.6) | 0 (0) | 3 (6.8) | 0.284 |
| ENT involvement | 9 (10.8) | 3 (7.7) | 6 (13.6) | 0.606 |
| Hematologic involvement | ||||
| Leukopenia | 4 (4.8) | 2 (5.1) | 2 (4.5) | 1.000 |
| Anemia | 69 (83.1) | 29 (74.4) | 40 (90.9) | 0.044 |
| Thrombocytopenia | 11 (13.3) | 6 (15.4) | 5 (11.4) | 0.590 |
| MAS | 1 (1.2) | 0 (0) | 1 (2.3) | 1.000 |
| TTP | 1 (1.2) | 0 (0) | 1 (2.3) | 1.000 |
| Infection | ||||
| Pneumonia | 72 (86.7) | 30 (76.9) | 42 (95.5) | 0.013 |
| Urinary tract infection | 3 (3.6) | 0 (0) | 3 (6.8) | 0.284 |
| Sepsis | 9 (10.8) | 2 (5.1) | 7 (15.9) | 0.221 |
| Shock | 27 (32.5) | 2 (5.1) | 25 (56.8) | <0.001 |
Values highlighted in bold represent statistically significant P values (P < 0.05).
a
Other neuropsychiatric disease including one patient with seizure, one with uremic encephalopathy and one with lower-extremity numbness.
AAV, antineutrophil cytoplasmic antibody-associated vasculitis; ICU, intensive care unit; ENT, Ear, Nose, and Throat; MAS, macrophage activation syndrome; TTP, thrombotic thrombocytopenic purpura.