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Schematics of SCF, FBXW7, and FBXW7 isoforms. (A) SCFFBXW7 consists of a scaffold cullin-1 (CUL-1), an adaptor SKP1, a RING-domain protein (RBX1/RBX2), and a substrate-receptor F-box protein (FBXW7). Shown is SCFFBXW7 complex in FBXW7 dimerization format for ubiquitylation of a substrate. (B) Three FBXW7 isoforms (α, β, and γ) with domain alignment. NLS, nuclear localization signal; TMD, transmembrane domain; DD, dimerization domain.
