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FBXW7 in regulation of DNA repair. Under unstressed condition, FAAP20 binds FANCA to facilitate mono-ubiquitylation of FANCD2. Upon DDR, FAAP20 was phosphorylated by GSK3β to facilitate FBXW7 binding and ubiquitylation. On the other hand, DNA-PKcs phosphorylated XRCC4, whereas ATM phosphorylated FBXW7. At the damage site, FBXW7 promoted XRCC4 polyubiquitylation via the K63 linkage to facilitate recruitment of Ku70/Ku80 for NHEJ repair.
