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Ciliary signaling in pre-adipocytes. Multiple receptors localize to the pre-adipocyte primary cilium and activation of ciliary signaling pathways can either promote or inhibit adipogenesis. Specifically, Hedgehog signaling has been shown to inhibit MSC commitment to adipogenesis. In contrast, the ciliary IGF-1 receptor and ciliary FFAR4/GPR120 are expressed in committed pre-adipocytes, and activation of these ciliary signaling pathways promotes adipogenesis.
