Table 3.

Univariate and multivariate analyses of factors influencing iPFS of 180 SCLC patients with BM.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	p-value	HR (95% CI)	p-value
Age, years
<60/≥60	1.45 (1.04–2.07)	0.026	1.35 (0.97–1.88)	0.078
Sex
Female/Male	1.53 (1.00–2.33)	0.051
Smoking
No/Yes	1.00 (0.73–1.38)	0.981
KPS
≤80/>80	0.81 (0.59–1.12)	0.199
DS-GPA
≤2.0/>2.0	0.77 (0.56–1.06)	0.110
Number of BMs
1–5/>5	1.53 (1.06–2.20)	0.024	1.43 (0.99–2.08)	0.060
Maximum diameter of BM, cm
≤2.0/> 2.0	1.12 (0.81–1.54)	0.485
Symptoms of BM
No/Yes	0.92 (0.69–1.26)	0.578
Extracranial metastasis
No/Yes	1.07 (0.72–1.58)	0.740
Treatment
WBRT/WBRT + boost	0.62 (0.45–0.86)	0.004	0.63 (0.46–0.88)	0.006
Radiation type
3D-CRT/IMRT	0.84 (0.60–1.18)	0.315

iPFS, intracranial progression-free survival; HR, hazard ratio; CI, confidence interval; WBRT, whole brain radiotherapy; WBRT + boost, whole brain radiotherapy plus local radiation boost; KPS, Karnofsky Performance Status; BM, brain metastasis; DS-GPA, diagnosis-specific graded prognostic assessment.

The bold values inidicate p-value is less than 0.05.