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. 2021 Oct 25;11:762147. doi: 10.3389/fonc.2021.762147

Table 1.

Inclusion, exclusion, and withdrawal criteria.

Inclusion criteria Exclusion criteria Withdrawal criteria
• 18 years < age < 85 years • BMI > 30 kg/m (2) • Intraoperative or pathological confirmation of invasion of adjacent structures or distant metastasis
• Pathological or highly suspected colorectal carcinoma • The lower border of the tumor is located distal to the peritoneal reflection • Non-colorectal adenocarcinoma confirmed by postoperative pathology
• Tumor located in the colon and rectum (the lower border of the tumor is above the peritoneal reflection) • Previous gastrointestinal surgery (apart from appendicectomy) • Requirement of emergency operation due to the change of illness state
• Clinically diagnosed cT1–4aN0–2M0 lesions according to the seventh Edition of AJCC Cancer Staging Manual • Emergency operation due to complication caused by colorectal cancer (bleeding, perforation, or obstruction) • Inability to undergo surgery or anesthesia due to the change of illness state
• Tumor size of ≤5 cm • Requirement of simultaneous surgery for other disease • Unable to complete the clinical trial due to various reasons
• Performance status ECOG 0–1 • Pregnancy or lactation • Patient required to withdraw
• ASA class I to III • Severe mental disease
• Informed consent • Simultaneous or metachronous multiple cancers with disease-free survival ≤5 years

BMI, body mass index; ASA, The American Society of Anesthesiologists; ECOG, Eastern Cooperative Oncology Group.