Table 2.

Literature Review of Case Reports on Insulin Desensitization in Patients With T1D

Report	Patient age	Duration of protocol	Insulin used	Premedications
Insulin allergy and resistance successfully treated by desensitization with Aspart insulin	25 years old	16 d	Aspart	Prednisolone
Insulin desensitization with insulin lispro and an insulin pump in a 5-year-old child	5 years old	8 h	Lispro	Cetirizine
Insulin allergy desensitization with simultaneous intravenous insulin and continuous subcutaneous insulin infusion	9 years old (2 cases)	192 h	Lispro	Fexofenadine
Successful treatment of insulin allergy in a type 1 diabetic patient by means of constant subcutaneous pump infusion of insulin	21 years old	Not reported	Lispro	Cetirizine
Continuous subcutaneous insulin infusion to resolve an allergy to human insulin	43 years old	22 h	Lispro	Not reported
Continuous subcutaneous insulin infusion allows tolerance induction and diabetes treatment in a type 1 diabetic child with insulin allergy	8 years old	36 h	Lispro	Not reported
Immediate-type human insulin allergy successfully treated by continuous subcutaneous insulin infusion	63 years old	4 d	Novolin R	Not reported
Primary systemic allergy to human insulin: recurrence of generalized urticaria after successful desensitization	22 years old	12 d	Humulin R	Not reported
Prolonged desensitization required for treatment of generalized allergy to human insulin	30 years old	9 d	Actrapid	Not reported
Successful management of insulin allergy and autoimmune polyendocrine syndrome type 4 with desensitization therapy and glucocorticoid treatment	17 years old	5 d	Glargine	Ebastine, prednisolone