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. 2021 Oct 25;11:734416. doi: 10.3389/fcimb.2021.734416

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Copyright © 2021 Xie, Cho, Lin, Pillai, Heimisdottir, Bandyopadhyay, Zou, Roach, Divaris and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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For DNA, RNA, and both in each study and the testing set, this shows the scatter plot of Spearman correlation in ENVIM (y-axis) and MelonnPan (x-axis). Spearman correlation is based on observed metabolite abundance and predicted values. Here, “Both ≥0.3” refers to the category of metabolites that have Spearman correlation ≥0.3 in both ENVIM- and MelonnPan-predicted results. “ENVIM ≥0.3” refers to the category of metabolites that have Spearman correlation ≥0.3 only between ENVIM-predicted and observed values.