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. 2021 Oct 25;12:731025. doi: 10.3389/fphys.2021.731025

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Copyright © 2021 Nowak, Veeraraghavan, Poelzing and Weinberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conduction velocity (CV) depends on key cellular and tissue properties. CV is shown as a function of cell size for different values of Na⁺channel densities (ρ_Na) for low (A), moderately low (B), moderately high (C), and high (D) GJ coupling and 10% (left), 50% (middle), and 90% (right) Na⁺channel ID localization (ID_Na). Parameters: Cleft width w = 20nm. Parameter regimes associated with neonatal (gray boxes) and adult (black boxes) tissue are highlighted.