Figure 3.

Skin ILC2s. Expression of different receptors on skin ILC2s and cellular interactions within this tissue. ILC2s in the skin interact with different cell populations, including epithelial cells and other components of the immune system. Signals from IL-33, IL-25, TSLP, IL-2, IL-4, IL-7, IL-18 and PGD2 receptors favor ILC2 function in this tissue. Klrg1 on ILC2s can interact with E-cadherin to negatively regulate these cells in the skin. Other receptors such as KIT and ICOS have also been reported in skin ILC2s although their specific function has yet to be determined. SCF, stem cell factor; PG, prostaglandin; LT, leukotriene.