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. 2021 Oct 25;12:759337. doi: 10.3389/fphar.2021.759337

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Copyright © 2021 Siegemund, Oak, Hansbauer, Allersdorfer, Utschick, Winter, Grasmüller, Galler, Mayer, Weiche, Prassler, Kontermann and Rothe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pharmacokinetics of Anticalin proteins in mice. (A, B) The serum concentrations after i.v. administration of 1.2–2.0 mg per kg bodyweight of Anticalin or Duocalin proteins with or without HLE module in CD-1 mice were analyzed by ELISA (n = 3, mean ± S.D.). (A) Comparison of serum concentrations over time for OX40 or NGAL Anticalin proteins. (B) The serum concentrations of corresponding Duocalin proteins were plotted against the PK of OX40 Ac-ABD (left) or OX40 Ac-IgBD (right). (C) The plasma concentrations after i.v. administration of 5 mg/kg Anticalin equivalent of OX40 Ac, OX40 Ac-ABD and OX40 Ac-Fc in hSA/hFcRn double humanized mice were analyzed by ECLA (n = 3, mean ± S.D.).