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. 2021 Oct 25;9:746317. doi: 10.3389/fcell.2021.746317

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Copyright © 2021 Zhang, Lei, Meng, Liu, Li, Zhang, Zhang, Tao, Peng, Lin and Ji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Iguratimod ameliorated myocardial injury and infiltration of inflammatory cells after I/R. (A) Representative images of Evans blue and TTC double-stained heart sections. (B) Comparison of AAR/LV ratio and IA/AAR ratio among the three groups based on the results of A. n = 5. (C) The level of cTnI in serum determined by ELISA. n = 5. (D) Representative HE staining pictures of hearts from mice in three groups. Scale bar = 50 μm. (E) Representative immunohistochemistry staining images of MPO in cardiac tissue. Scale bar of the first row = 50 μm and scale bar of the second row = 20 μm. (F) Comparison of the MPO positive stained area among the three groups. n = 4. Data are expressed as mean ± SD; **p < 0.01 versus Sham group; ^##p < 0.01 versus I/R group. I/R, ischemia/reperfusion; AAR, area at risk; LV, left ventricle; IA, infarct area; cTnI, cardiac troponin I; MPO, myeloperoxidase.