Skip to main content
. 2021 Oct 25;9:746317. doi: 10.3389/fcell.2021.746317

FIGURE 7.

FIGURE 7

Iguratimod ameliorated pyroptosis and the expression of pro-inflammatory cytokines of CFs subjected to H/R through inhibiting the COX2/NLRP3 signaling pathway. (A–F) Relative mRNA expression levels of COX2, NLRP3, IL-1β, IL-18, IL-6, and TNF-α among Con, H/R and T + H/R group. n = 4. (G) Representative Western blotting luminogram of COX2, NLRP3, caspase-1, ASC, cleaved caspase-1, GSDMD-N, and IL-1β of the three groups. (H–N) Protein semiquantification standardized by β-Tubulin. n = 5. Data are expressed as mean ± SD; *p < 0.05, **p < 0.01 versus Con group; ##p < 0.01 versus H/R group. CFs, cardiac fibroblasts; H/R, hypoxia/reoxygenation.