TABLE 1.

EFs and the UF–LC/MS data of the bioactive compounds bound to Topo I, Topo II, COX-2, and ACE2 from the crude extracts of P. sinense.

Peak No.	Rt a (min)	EFs b (%)				[M+H]+	Characteristic fragment (m/z)	Identification
		Topo I	Topo II	COX-2	ACE2
1	13.88	—	0.20	—	—	465	465, 303, 85	Quercetin 3-O-glucoside c
2	14.92	0.37	0.18	—	0.22	449	449, 287	Kaempferol 3-O-glucoside c
3	16.02	—	0.49	1.49	—	415	313, 298, 282, 229	Podophyllotoxin isomer d
4	17.98	9.36	2.86	4.40	2.76	543	381, 363, 351, 333, 305	Cleistanthin B isomer d
5	18.37	2.38	1.15	1.39	0.65	397	397, 313, 282, 229	β-Apopicropodophyllin d
6	19.49	3.07	0.90	1.14	1.37	543	381, 363, 351, 333, 305	Diphyllin O-glucoside c
7	21.98	0.48	1.04	—	3.10	287	287, 241, 213, 165, 153	Kaempferol c
8	22.64	3.89	1.17	1.61	1.31	415	397, 313, 282, 247, 229	Podophyllotoxin c
9	24.59	—	1.08	—	—	395	395, 380, 351, 336, 320	Chinensinaphthol methyl ether d
10	25.88	4.41	0.26	5.25	3.68	381	381, 363, 351, 333, 305	Diphyllin c

^aRt, retention time.

^bEFs, enrichment factors.

^cCompared with the corresponding standards.

^dIdentified based on the published literature.