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Neutralising antibody responses. Serum samples were assayed for SARS-CoV-2 neutralizing antibodies using a pseudo-neutralisation assay based on inhibition of binding of ACE2 receptor to the SARS-CoV-2 spike protein of the Wuhan strain (a) or the alpha (b), beta (c), gamma (d) and delta variants (e). Data are shown as median and interquartile range (IQR). ****p<0•0001 [Wilcoxon matched-pairs, two-tailed rank test].
