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. Author manuscript; available in PMC: 2021 Nov 8.
Published in final edited form as: Neuron. 2020 Jan 13;105(5):921–933.e5. doi: 10.1016/j.neuron.2019.12.006

Figure 2. Development of responses in VP neurons during learning.

Figure 2.

(A) The responses to reward cue (CS) or reward (US) in an example PVN tracked over multiple sessions (S1-S9). Responses are shown as spike density plots. (B) CS-US (reward) response index for all PVNs across different stages of training (r2 = 0.69, P < 0.001 by linear regression). (C) Z-score activity plots of the responses of all PVNs during reward and punishment blocks. Each row represents the activities of one neuron. Neurons are sorted according to their CS/US response ratio. (D) The CS-US response index for all NVNs in the punishment block across different stages of training (r2 = 0.41, P < 0.05 by linear regression). (E) The CS and US responses of two example NVNs in the punishment block at different stages of training. Responses are shown as spike density plots. (F) Z-score activity plots of the responses of all NVNs during reward and punishment blocks. Each row represents the activities of one neuron. Neurons are sorted according to their CS/US response ratio.