Fig. 5.

Multiple sequence alignment of dUTPases between different viruses and humans. The five highly-conserved domains typical of dUTPases are indicated above the sequences. The functional region of PRV UL50 in charge of anti-IFN activity reported by Zhang (2017) is marked by a purple rectangle. The sequences of the following dUTPases are as follows: MVV (GI:9626549), CAEV (GI:266706151), EIAV (GI:323836), MHV68 (GI:114782444), PRV (GI: 51557490), and humans (GI:4503423). CAEV: Caprine arthritis-encephalitis virus, EIAV: Equine infectious anemia virus, MVV: Maedi-visna virus, MHV: Mouse hepatitis virus, ORF: Open reading frame, PRV: Pseudorabies virus, and IFN: Interferon