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. 2021 Oct 25;11:757919. doi: 10.3389/fonc.2021.757919

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Copyright © 2021 Liu, Weng, Xu, Wang, Liu, Zhang, Guo, Dang, Xing, Lu and Han

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction and validation of TAMIS. (A) Determination of the optimal lambda was obtained when the partial likelihood deviance reached the minimum value. and further generated the key miRNAs with nonzero coefficients. (B) LASSO coefficient profiles of the candidate miRNAs for TAMIS construction. (C, D) Kaplan-Meier curves of OS according to TAMIS in GSE53870 (C) and TCGA-CHOL (D–F). Multivariable Cox regression analysis of TAMIS in GSE53870 (E) and TCGA-CHOL (F). (G, H) Time-dependent ROC analysis for predicting OS at 1, 2, 3, 4, and 5 years in GSE53870 (G) and TCGA-CHOL (H).