Fig. 3.

Pancreas progenitors in the adult pancreas. Both exocrine and endocrine cells in the adult pancreas retain some plasticity when challenged with different triggers (oncogenic mutations, injury). Although the cell of origin for the different types of endocrine tumours is still unclear, ductal and acinar progenitor cells can become neoplastic after undergoing oncogenic mutations to generate PDACs or IPMN. During homeostasis and upon some injuries centro acinar cells (CAC), ductal cells and Procr+  intraislet progenitors can differentiate to β-cells both in vivo and in vitro.